I'm no hairy-o-die-nammie-sist but it does make a difference. I think that if set in the right place it can slow the air coming off the front of the screen and blend the airflows together. I have fitted my Madstad and touring Vario screen and been out on the M4 experimenting (I stopped away from junctions to make changes, not on the hard shoulder) I have found as close to perfect as I have got so far, with the blade right up and out.
The key to making / fitting one is making sure it's easily adjustable, it's one of the dark arts setting up the aerodynamics (there, got it right!) as it's different for everyone.