Yes they did. Back in 1966 to beat the Suzuki and Yamaha 2 strokes Honda built a 5 cylinder 125 with 4 valves per cylinder, capable of running up to 22,000rpm and had a nine speed gearbox. Good for over 130mph. I saw it at Brands Hatch around that time. Probably the loudest bike I've ever heard, along with the 6 cylinder 250 and 297cc bikes that Honda also had running then.